As part of the Emerging Researchers Seminar Series, celebrating the 40th anniversary of LOEX, the student committee of the Regenerative Medicine axis is pleased to invite you to its first seminar.

We will have the privilege of welcoming Poppy Smith, a postdoctoral researcher at Queen Mary University of London. An expert in peripheral nerve regeneration through the application of tissue engineering, she will share with us her latest findings and advancements in this exciting field.

Don’t miss this unique opportunity to learn more about the progress of regenerative medicine. We hope to see you there!

Date and Time: Thursday, June 19 at 12:00 PM
TEAM LINK
Meeting ID: 269 434 371 249 1
Passcode: g8QX34io

Harnessing endothelial cells and automation in peripheral nerve regeneration

Traumatic peripheral nerve injury has a sudden, debilitating effect on millions of people every year, resulting in loss of sensation and movement, significantly reducing quality of life. Fortunately, the peripheral nerves have the capacity to regenerate. The standard clinical treatment to repair peripheral nerve injuries which result in a gap in the nerve tissue is the nerve autograft. The autograft has multiple limitations, including donor site morbidity and availability, donor-recipient nerve mismatches, and poor patient satisfaction. Tissue engineering offers a promising alternative to the nerve autograft to support nerve regeneration: engineered neural tissue (EngNT) constructs comprised of aligned cells in an aligned collagen matrix. Cell source and production time can limit the clinical translatability of nerve repair constructs. Here, a novel source of endothelial cells was derived from hiPSCs, for which GMP equivalents are available, and incorporated into EngNT constructs to mimic key endothelial structures in the nerve regeneration process. The production of these EngNT constructs was also advanced to an automated technique, capable of producing nerve repair constructs in a scalable fashion.