Date: Vendredi 10 avril 2026
Heure: 11:00
Lieu: Salle F-1455
Centre de recherche CERVO
Quebec, Quebec G1J 2G3

Une présentation de Manon Defaye, Professeure adjointe sous octroi, Département de médecine moléculaire, Université Laval
Axe neurosciences, Centre de recherche du CHU de Québec–Université Laval

Pain and inflammation are integrated biological responses that alert an organism to the presence of injury or infection. Acute pain, associated with actual or threatened tissue damage, is adaptive and protective. However, under pathophysiological conditions, this response can persist even after the resolution of inflammation, leading to chronic pain. Inflammatory bowel diseases (IBDs) are chronic, relapsing gastrointestinal (GI) disorders associated with visceral pain. While the primary goal of IBD therapy is to prevent flares and control inflammation, many treated patients continue to experience visceral hypersensitivity despite being in endoscopic remission, suggesting a high level of neuroplasticity in the ascendent pain pathway. Understanding the complex neural pathways and molecular signaling involved in visceral pain perception is crucial for developing targeted interventions and improving patient outcomes.