Bonjour à toutes et à tous,

L’axe Neurosciences vous invite à la conférence de la Dre Aparna Suvrathan, McGill University, le jeudi 25 septembre à 10h.

La conférence est proposée en format hybride, en présentiel au LOEX, salle R138 et diffusée sur zoom (https://us02web.zoom.us/j/82060367248).

Pour les chercheurs qui souhaitent une discussion avec la conférencière, merci de contacter Julia Hernandez-Rapp Julia.Hernandez-Rapp@crchudequebec.ulaval.ca d’ici lundi 22 septembre.

Pour les étudiants et professionnels, une rencontre avec boîtes à lunch offerte est prévue juste après la conférence si vous souhaitez discuter avec la conférencière. Merci d’écrire à Julia.Hernandez-Rapp@crchudequebec.ulaval.ca dès que possible pour vous inscrire à cette rencontre, les places sont limitées à 10 personnes.

Voici le titre de la présentation :

Titre de la conférence : Synaptic heterogeneity shapes cerebellar function

Résumé : The cerebellum supports diverse functions, from motor to cognitive. However, the circuit architecture of the cerebellum appears to be stereotyped and uniform across regions. One way in which the seemingly similar circuits of the cerebellum can support diverse functions is through diversity in cellular properties. Recently, we discovered that synaptic properties and plasticity at parallel fiber to Purkinje cell synapses were surprisingly diverse across different cerebellar lobules in the mouse. This heterogeneity was manifested as differences in the timing of slow synaptic currents, which can vary by hundreds of milliseconds. As a consequence of these varied synaptic timing properties, Purkinje cells transformed synaptic input into firing output over a wide range of timescales. Moreover, we found that heterogeneity in the underlying signaling pathways also resulted in heterogeneity in synaptic plasticity across lobules. Thus, the computations performed by synapses in different regions of the cerebellum were remarkably diverse. In addition, this particular form of synaptic plasticity is of key relevance to Fragile X syndrome, in which the cerebellum has been strongly implicated. Strikingly, we demonstrated that synaptic plasticity was impaired in a mouse model of Fragile X syndrome, in a manner that disrupted the normal pattern of heterogeneity.